Deoxyarbutin

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Chemical Structure| 53936-56-4 同义名 : -
CAS号 : 53936-56-4
货号 : A243777
分子式 : C11H14O3
纯度 : 98%
分子量 : 194.227
MDL号 : MFCD09970981
存储条件：

Pure form Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(540.6 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • tyrosinase

    tyrosinase, IC50:50 nM
描述 Deoxyarbutin, a potent inhibitor of tyrosinase, could act as substrate of the enzyme. Oxytyrosinase is able to hydroxylate deoxyarbutin and finishes the catalytic cycle by oxidizing the formed o-diphenol to quinone, while the enzyme becomes deoxytyrosinase, which evolves to oxytyrosinase in the presence of oxygen[3]. dA (Deoxyarbutin) has potential tyrosinase inhibitory activity that can result in skin lightening and may be used to ameliorate hyperpigmentary lesions[4]. The in vivo finding also revealed that administration of dA (Deoxyarbutin) significantly decreased the tumour volume and tumour metastasis in B16F10 xenograft model by inhibiting tumour proliferation and inducing tumour apoptosis. dA was specific against tumour cell lines and had no observed systemic toxicity in vivo. dA could combate tumour in vitro and in vivo by inhibiting the proliferation and metastasis of tumour via a p38-mediated mitochondria associated apoptotic pathway[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.15mL

1.03mL

0.51mL

25.74mL

5.15mL

2.57mL

51.49mL

10.30mL

5.15mL
参考文献

[1]Lin CC, Yang CH, et al. Study on the stability of deoxyArbutin in an anhydrous emulsion system. Int J Mol Sci. 2011;12(9):5946-54.

[2]Boissy RE, Visscher M, DeLong MA. DeoxyArbutin: a novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency. Exp Dermatol. 2005 Aug;14(8):601-8.

[3]Garcia-Jimenez A, Teruel-Puche JA, Garcia-Ruiz PA, Saura-Sanmartin A, Berna J, Garcia-Canovas F, Rodriguez-Lopez JN. Structural and kinetic considerations on the catalysis of deoxyarbutin by tyrosinase. PLoS One. 2017 Nov 14;12(11):e0187845

[4]Boissy RE, Visscher M, DeLong MA. DeoxyArbutin: a novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency. Exp Dermatol. 2005 Aug;14(8):601-8

[5]Ma L, Xu Y, Wei Z, Xin G, Xing Z, Niu H, Huang W. Deoxyarbutin displays antitumour activity against melanoma in vitro and in vivo through a p38-mediated mitochondria associated apoptotic pathway. Sci Rep. 2017 Aug 3;7(1):7197