Nilutamide

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Chemical Structure| 63612-50-0 同义名 : RU 23908;Nilandron;NILANDRON 55dimethyl34nitro3(trifluoromethyl)phenyl24imidazolidinedione
CAS号 : 63612-50-0
货号 : A242214
分子式 : C12H10F3N3O4
纯度 : 99%
分子量 : 317.221
MDL号 : MFCD00864670
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(788.09 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Nilutamide (Nilandron) is an orally active, nonsteroidal androgen receptor antagonist that binds to androgen receptors without affinity for progestogen, estrogen, or glucocorticoid receptors. Nilutamide is used in prostate cancer research and possesses antischistosomal properties[1][4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.15mL

0.63mL

0.32mL

15.76mL

3.15mL

1.58mL

31.52mL

6.30mL

3.15mL
参考文献

[1]Harris MG, et al. Nilutamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in prostate cancer. Drugs Aging. 1993 Jan-Feb;3(1):9-25.

[2]Babany G, et al. Inhibitory effects of nilutamide, a new androgen receptor antagonist, on mouse and human liver cytochrome P-450. Biochem Pharmacol. 1989 Mar 15;38(6):941-7.

[3]Simard J, et al. Comparison of in vitro effects of the pure antiandrogens OH-flutamide, Casodex, and nilutamide on androgen-sensitive parameters. Urology. 1997 Apr;49(4):580-6; discussion 586-9.

[4]Keiser J, Vargas M, Vennerstrom JL. Activity of antiandrogens against juvenile and adult Schistosoma mansoni in mice. J Antimicrob Chemother. 2010 Sep;65(9):1991-5.