生物活性 | |||
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靶点 |
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描述 | CHIR-124 is a potent Chk1 inhibitor with IC50 of 0.3 nM with 2,000-fold selectivity against Chk2, 500- to 5,000-fold less activity against CDK2/4 and Cdc2. |
细胞研究 | |||||
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细胞系 | 浓度 | 检测类型 | 检测时间 | 活动说明 | 数据源 |
human MDA-MB-435 cells | Cytotoxic assay | Cytotoxicity against human MDA-MB-435 cells, EC50=0.08 μM | 16603354 | ||
human MDA-MB-435 cells | Cytotoxic assay | Cytotoxicity against human MDA-MB-435 cells in presence of camptothecin | 16603354 |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.38mL 0.48mL 0.24mL |
11.91mL 2.38mL 1.19mL |
23.81mL 4.76mL 2.38mL |
参考文献 |
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