产品说明书

Taurolidine

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Chemical Structure| 19388-87-5 同义名 : Tauroflex;Taurolin;Tauroline
CAS号 : 19388-87-5
货号 : A241743
分子式 : C7H16N4O4S2
纯度 : 97%
分子量 : 284.356
MDL号 : MFCD00865076
存储条件：

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(211 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Taurolidine is a broad-spectrum antiseptic used as lock therapy solution in adult and pediatric patients with long term central venous catheters (CVC) for the prevention of catheter related bloodstream infections (CRBSI). Taurolidine doesn't induce the resistant development and has only minor and brief side effects[1]. A 48 hours exposure of human erythrocytes to Taurolidine (60 µg/ml) significantly enhanced the percentage of annexin-V-binding cells, significantly decreased forward scatter and significantly increased Fluo3-fluorescence and ceramide abundance, but not DCF(2',7'-dichlorodihydrofuorescein)-fluorescence[2]. In HepaRG cell cultures, hepatocyte adherence was significantly decreased, cell death and cleaved caspase-3 were significantly increased after administration of taurolidine in a dose-dependent manner. High-dose application of taurolidine led to elevated liver enzymes and IL-6 secretion in hepatic organoid. After 24 h a significant increase of serum GLDH and ASAT was observed in rats treated with high-dose taurolidine treatment[3]. There was no growth at 0.12% taurolidine and light growth at 0.06% for all isolates. Taurolidine was reliable at inhibiting growth of MRSP (methicillin-resistant Staphylococcus pseudintermedius) at a concentration of 1,200 µg/mL[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.52mL

0.70mL

0.35mL

17.58mL

3.52mL

1.76mL

35.17mL

7.03mL

3.52mL
参考文献

[1]Haro C. Taurolidina, un antiséptico para la prevención de infecciones asociadas a catéter venoso central [Taurolidine, an antiseptic for the prevention of central venous catheter-related infections]. Rev Chilena Infectol. 2019;36(4):414‐420

[2]Fink M, Al Mamun Bhuyan A, Zacharopoulou N, Lang F. Taurolidine Sensitivity of Eryptosis, the Suicidal Erythrocyte Death. Cell Physiol Biochem. 2018;51(2):501‐512

[3]Fahrner R, Möller A, Press AT, et al. Short-term treatment with taurolidine is associated with liver injury. BMC Pharmacol Toxicol. 2017;18(1):61. Published 2017 Aug 11

[4]Wormhoudt T, Séguin B, Bemis DA, Hyatt D. Taurolidine susceptibility of methicillin-resistant Staphylococcus pseudintermedius isolates. J Vet Diagn Invest. 2017;29(6):910‐911