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Kojic acid

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Chemical Structure| 501-30-4 同义名 : NSC 1942
CAS号 : 501-30-4
货号 : A240690
分子式 : C6H6O4
纯度 : 98%
分子量 : 142.109
MDL号 : MFCD00006580
存储条件：

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(738.87 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(351.84 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Kojic Acid, an inhibitor of tyrosinase, is often used as an antimelanogenic agent in cosmetic [1] . Besides of the application in cosmetic, kojic acid is also a potential drug molecule. In vitro studies, after treatment with 600 μg/ml kojic acid, the tyrosinase activity in human SK-MEL2 cells would decrease 33.9±1.4% [2] . In addition, kojic acid could also suppress the activity of NF-kappaB in transfectant human HaCaT and SCC-13 cells [3] . In vivo studies, it was found that kojic acid could increase the 30-day survival rate of C57BL/6 mice, after the treatment with the lethal gamma-irradiation [4] .
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

7.04mL

1.41mL

0.70mL

35.18mL

7.04mL

3.52mL

70.37mL

14.07mL

7.04mL
参考文献

[1]Singh BK, Park SH, et al. Kojic Acid Peptide: A New Compound with Anti-Tyrosinase Potential. Ann Dermatol. 2016;28(5):555-561.

[2]Srisayam M, Weerapreeyakul N, et al. Application of FTIR microspectroscopy for characterization of biomolecular changes in human melanoma cells treated by sesamol and kojic acid. J Dermatol Sci. 2014;73(3):241-50.

[3]Moon KY, Ahn KS, et al. Kojic acid, a potential inhibitor of NF-kappaB activation in transfectant human HaCaT and SCC-13 cells. Arch Pharm Res. 2001;24(4):307-11.

[4]Wang K, Liu C, et al. Kojic acid protects C57BL/6 mice from gamma-irradiation induced damage. Asian Pac J Cancer Prev. 2014;15(1):291-7.