产品说明书

Tesofensine

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Chemical Structure| 195875-84-4 同义名 : NS-2330
CAS号 : 195875-84-4
货号 : A239666
分子式 : C17H23Cl2NO
纯度 : 95%
分子量 : 328.277
MDL号 : MFCD18633271
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 2 mg/mL(6.09 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Tesofensine (NS-2330) is a powerful triple monoamine reuptake inhibitor that blocks the reuptake of dopamine (DA; IC50=6.5 nM), norepinephrine (NE; IC50=1.7 nM), and serotonin (5-HT; IC50=11 nM), and is investigated as a potential anti-obesity agent[1]. Tesofensine acts as a central nervous system (CNS) anti-obesity agent[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.05mL

0.61mL

0.30mL

15.23mL

3.05mL

1.52mL

30.46mL

6.09mL

3.05mL
参考文献

[1]Lieuwe Appel, et al. Tesofensine, a novel triple monoamine re-uptake inhibitor with anti-obesity effects: dopamine transporter occupancy as measured by PET. Eur Neuropsychopharmacol. 2014 Feb;24(2):251-61.

[2]Ann A Coulter, et al. Centrally Acting Agents for Obesity: Past, Present, and Future. Drugs. 2018 Jul;78(11):1113-1132.

[3]Anne Marie D Axel, et al. Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat.Neuropsychopharmacology. 2010 J