产品说明书
Sodium Butyrate
 |
同义名 : | 正丁酸钠 ;Butyric Acid;NaB;Butanoic acid sodium salt |
| CAS号 : | 156-54-7 | |
| 货号 : | A239433 | |
| 分子式 : | C4H7NaO2 | |
| 纯度 : | 95% | |
| 分子量 : | 110.087 | |
| MDL号 : | MFCD00002816 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Sodium Butyrate is the sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). This binding affects hyperacetylation of histones, resulting in a modified DNA conformation, which subsequently leads to the uncoiling or relaxing of chromatin. NaB (sodium butyrate) corrected the HFD(high-fat diet)-induced gut microbiota imbalance in mice[3]. Sodium butyrate (NaB) increases α-Synuclein mRNA expression, enhances Atg5-mediated autophagy in murine neuroendocrine STC-1 cells. Moreover, the PI3K/Akt/mTOR pathway was significantly inhibited and cell apoptosis was activated by NaB. NaB-stimulated STC-1 cells induced inflammation in SH-SY5Y cells[4]. NaB prevents excessive ROS through NOX2 (NADPH oxidase 2) suppression and SOD1 (superoxide dismutase 1) upregulation by p21/NRF2 pathway, which is critical for inhibiting BACE1-dependent amyloidogenesis in neuronal cells exposed to high cholesterol environment[5]. In vivo, SB (Sodium Butyrate) significantly ameliorated the inflammatory response and intestinal epithelium barrier dysfunction in TNBS (2,4,6-trinitrobenzene sulfonic acid)-induced WT mice. In vitro, pre-treatment with SB dramatically inhibited the expression of TNF-α and IL-6 in LPS-induced RAW246.7 macrophages[6]. | ||
| 细胞研究 | |||||
|---|---|---|---|---|---|
| 细胞系 | 浓度 | 检测类型 | 检测时间 | 活动说明 | 数据源 |
| human H1299 cells | Function assay | 7 days | Inhibition of human USP1/UAF1 in human H1299 cells assessed as reduction in colony formation after 7 days, EC50=3 μM | 25229643 | |
| human JEG3 cells | Function assay | Inhibition of aromatase in human JEG3 cells by scintillation spectrometry, IC50=0.0015 μM | 20148564 | ||
| human K562 cells | 1 mM | Proliferation assay | Antiproliferative activity against human K562 cells at 1 mM in presence of guanosine | 23937979 | |
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01862380 | Adrenal Hyperplasia, Congenita... 展开 >>l 21-hydroxylase Deficiency 收起 << | Not Applicable | Unknown | November 2016 | France ... 展开 >> Assistance Publique - Hôpitaux de Paris, Bicêtre Hospital Le Kremlin-bicetre, France, 94 275 收起 << |
| NCT03401398 | Septic Shock | Phase 3 | Not yet recruiting | April 30, 2023 | - |
| NCT03110198 | Ulcerative Colitis, Unspecifie... 展开 >>d 收起 << | Phase 4 | Recruiting | March 2018 | China, Shaanxi ... 展开 >> Xijing Digestive Disease Recruiting Xi'an, Shaanxi, China, 710032 Contact: Jie liang, professor 86-029-84771535 liangjie@fmmu.edu.cn 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
9.08mL 1.82mL 0.91mL |
45.42mL 9.08mL 4.54mL |
90.84mL 18.17mL 9.08mL |
| 参考文献 |
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