Cisapride
产品说明书
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同义名 : | 西沙比利 ;(±)-Cisaprid;R 51619;Propulsid;Pridesia;Presid;Prepulsid;Kinestase;Kaudalit |
| CAS号 : | 81098-60-4 | |
| 货号 : | A238567 | |
| 分子式 : | C23H29ClFN3O4 | |
| 纯度 : | 98% | |
| 分子量 : | 465.945 | |
| MDL号 : | MFCD00869327 | |
| 存储条件： |
Pure form Keep in dark place,Inert atmosphere,Room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(225.35 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
IP 2% DMSO+2% Tween80+40% PEG300+water 6 mg/mL clear PO 0.5% CMC-Na 35 mg/mL suspension |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Cisapride (R 51619) is an orally active 5-HT4 receptor agonist with an EC50 value of 140 nM. Cisapride is also an hERG blocker with an IC50 value of 9.4 nM. It functions as a gastroprokinetic agent, stimulating gastrointestinal motor activity[1][2][3][4]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00699894 | Postoperative Nausea and Vomit... 展开 >>ing 收起 << | Not Applicable | Withdrawn(Logistical difficult... 展开 >>ies running the study) 收起 << | - | United States, New York ... 展开 >> Long Island Jewish Medical Center/Schneider's Children Hospital New Hyde Park, New York, United States, 11040 收起 << |
| NCT02524496 | - | Completed | - | - | |
| NCT01281540 | Gastroparesis | Phase 4 | Terminated(Sponsor request) | - | - |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.15mL 0.43mL 0.21mL |
10.73mL 2.15mL 1.07mL |
21.46mL 4.29mL 2.15mL |
| 参考文献 |
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