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Hesperetin

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Chemical Structure| 520-33-2 同义名 : NSC 57654;(–)-3',5,7-Trihydroxy-4'-methoxyflavanone;Prestwick_908;YSO2;Hesperin;Hesperitin;(S)-Hesperetin;(–)-Hesperetin
CAS号 : 520-33-2
货号 : A238234
分子式 : C16H14O6
纯度 : 97%
分子量 : 302.279
MDL号 : MFCD00075646
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(396.98 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • Histamine receptor

  • TGF-β
描述 Hesperetin is an effective antioxidant and anti-inflammatory agent. Hesperetin conferred neuroprotection by regulating the TLR4/NF-κB (Toll-like receptor-4) signaling pathway against the detrimental effects of LPS(lipopolysaccharide) [3]. Hesperetin (HET) and naringenin (NGR) are flavanones found in citrus (oranges and grapefruit) and Aurantii Fructus Immaturus. HET and NGR displayed broad-spectrum inhibition against human UGTs. HET exhibited strong inhibitory effects on UGT1A1, 1A3 and 1A9 (both IC50 and Ki values lower than 10 µM) [4]. Hesperetin interacts with different types of proteins involving hydrogen bonds, pi-pi effects, pi-cation bonding and pi-sigma interactions with varying binding energies. Hesperetin exhibits drug-like properties which projects its potential as a therapeutic option for CHIKV infection[5]. Preadministration of Hesperetin (40 mg/kg b.w., oral) significantly attenuated the Cd-induced (cadmium) oxidative stress and mitochondrial dysfunction, restored the antioxidant and membrane-bound enzyme activities and decreased apoptosis in the brain of rats[6]. Hesperetin (200 mg/kg) attenuates Con A-induced hepatocyte apoptosis and hepatic Nos2 (iNOS) expression in mice. Hesperetin blocked bile acid-induced apoptosis and cytokine-induced inflammation in rat hepatocytes[7].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.31mL

0.66mL

0.33mL

16.54mL

3.31mL

1.65mL

33.08mL

6.62mL

3.31mL
参考文献

[1]Oo A, Hassandarvish P, et al. In silico study on anti-Chikungunya virus activity of hesperetin. PeerJ. 2016 Oct 26;4:e2602.

[2]Yang Y, Wolfram J, et al. Hesperetin: an inhibitor of the transforming growth factor-β (TGF-β) signaling pathway. Eur J Med Chem. 2012 Dec;58:390-5.

[3]Muhammad T, Ikram M, Ullah R, Rehman SU, Kim MO. Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammation, Apoptosis and Memory Impairments by Modulating TLR4/NF-κB Signaling. Nutrients. 2019;11(3):648. Published 2019 Mar 17

[4]Liu D, Wu J, Xie H, et al. Inhibitory Effect of Hesperetin and Naringenin on Human UDP-Glucuronosyltransferase Enzymes: Implications for Herb-Drug Interactions. Biol Pharm Bull. 2016;39(12):2052-2059

[5]Oo A, Hassandarvish P, Chin SP, Lee VS, Abu Bakar S, Zandi K. In silico study on anti-Chikungunya virus activity of hesperetin. PeerJ. 2016;4:e2602. Published 2016 Oct 26

[6]Shagirtha K, Bashir N, MiltonPrabu S. Neuroprotective efficacy of hesperetin against cadmium induced oxidative stress in the brain of rats. Toxicol Ind Health. 2017;33(5):454-468

[7]Bai X, Yang P, Zhou Q, et al. The protective effect of the natural compound hesperetin against fulminant hepatitis in vivo and in vitro. Br J Pharmacol. 2017;174(1):41-56