产品说明书
DL-alpha-Tocopherol
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同义名 : | 消旋-α-生育酚 ;DL-α-Tocopherol;rac-alpha-Tocopherol;5,7,8-Trimethyltocol;(±)-α-Tocopherol |
| CAS号 : | 10191-41-0 | |
| 货号 : | A238186 | |
| 分子式 : | C29H50O2 | |
| 纯度 : | 98% | |
| 分子量 : | 430.706 | |
| MDL号 : | MFCD00006848 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(243.79 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 100 mg/mL(232.18 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | (±)-α-Tocopherol is the compound demonstrating the highest vitamin E activity, which is available both in its natural form as RRR-alpha-tocopherol isolated from plant sources[1]. The alpha-tocopherol transfer protein (TTP) is a critical regulator of vitamin E status that stimulates the movement of vitamin E between membrane vesicles in vitro and facilitates the secretion of tocopherol from hepatocytes[2]. α-Tocopherol serves as a peroxyl radical scavenger that protects polyunsaturated fatty acids in membranes and lipoproteins. The biological activity of vitamin E is highly dependent upon regulatory mechanisms that serve to retain α-tocopherol and excrete the non-α-tocopherol forms. This preference is dependent upon the combination of the function of α-tocopherol transfer protein (α-TTP) to enrich the plasma with α-tocopherol and the metabolism of non-α-tocopherols[3]. In patients with Abetalipoproteinemia, tocofersolan and α-tocopherol acetate bioavailabilities were extremely low (2.8% and 3.1%, respectively) [4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.32mL 0.46mL 0.23mL |
11.61mL 2.32mL 1.16mL |
23.22mL 4.64mL 2.32mL |
