pemafibrate

产品说明书

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Chemical Structure| 848259-27-8 同义名 : K-877
CAS号 : 848259-27-8
货号 : A236714
分子式 : C28H30N2O6
纯度 : 99%
分子量 : 490.548
MDL号 : MFCD30533427
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Pemafibrateis a selective PPARα modulator (SPPARMα) that has antihyperlipidaemic activity.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.04mL

0.41mL

0.20mL

10.19mL

2.04mL

1.02mL

20.39mL

4.08mL

2.04mL
参考文献

[1]Hennuyer N, Duplan I, et al. The novel selective PPARα modulator (SPPARMα) pemafibrate improves dyslipidemia, enhances reverse cholesterol transport and decreases inflammation and atherosclerosis. Atherosclerosis. 2016 Jun;249:200-8.

[2]Ishibashi S, Yamashita S, et al. Effects of K-877, a novel selective PPARα modulator (SPPARMα), in dyslipidaemic patients: A randomized, double blind, active- and placebo-controlled, phase 2 trial. Atherosclerosis. 2016 Jun;249:36-43.