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4-Bromo-3-hydroxybenzoic acid

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Chemical Structure| 14348-38-0 同义名 : -
CAS号 : 14348-38-0
货号 : A236076
分子式 : C7H5BrO3
纯度 : 98%
分子量 : 217.02
MDL号 : MFCD08056371
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(483.83 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 4-Bromo-3-hydroxybenzoic acid (BHOA) is a metabolite of Brocresine and a histidine decarboxylase (HDC) inhibitor with IC50s of 1 mM for both rat fetal and rat gastric HDC, also inhibits aromatic-L-amino acid decarboxylase from hog kidney and rat gastric mucosa in vitro with IC50s of 1 mM for both enzymes[1]. BHOA and antihistamine diphenhydramine (DPHM) were injected intraperitoneally to test their effects on SD-induced (sleep deprivation) vertigo. Upregulated HDC in the vestibular and increased CSF (cerebrospinal fluid) concentration of histamine can be detected in the SD mice, indicating vestibular dysfunction which can be ameliorated by both BHOA and DPHM{Qian S, Wang Y, Zhang X. Inhibiting Histamine Signaling Ameliorates Vertigo Induced by Sleep Deprivation. J Mol Neurosci. 2019 Mar;67(3):411-417|https://pubmed.ncbi.nlm.nih.gov/30644035}}.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.61mL

0.92mL

0.46mL

23.04mL

4.61mL

2.30mL

46.08mL

9.22mL

4.61mL
参考文献

[1]Ellenbogen L, Kelly RG, Taylor RJ Jr, Stubbs CS Jr. Studies on the inhibition of histidine decarboxylase, aromatic-L-amino acid decarboxylase and acid secretion by brocresine and its metabolites. Biochem Pharmacol. 1973 Apr 15;22(8):939-47

[2]Qian S, Wang Y, Zhang X. Inhibiting Histamine Signaling Ameliorates Vertigo Induced by Sleep Deprivation. J Mol Neurosci. 2019 Mar;67(3):411-417