产品说明书
Malotilate
 |
同义名 : | NKK 105 |
| CAS号 : | 59937-28-9 | |
| 货号 : | A235461 | |
| 分子式 : | C12H16O4S2 | |
| 纯度 : | 98% | |
| 分子量 : | 288.38 | |
| MDL号 : | MFCD00867646 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(364.1 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Malotilate is a hepatoprotective agent that selectively inhibits 5-lipoxygenase with an IC50 value of 4.7μM[3]. Malotilate at concentrations of 0.1 – 100μM increased collagenase secretion in the multilayered cultures of normal human dermal fibroblasts, but not in the monolayers[4]. Pretreatment of rat lung endothelial (RLE) cells with malotilate (10 and 20ng/mL) for 24 h markedly inhibited the invasion of the RLE monolayer by c-SST-2 cells. In SHR rats inoculated with c-SST-2 tumors, administration with malotilate (300mg/kg/day), which started 7 days before or after c-SST-2 cell inoculation, significantly suppressed pulmonary metastatic compared with non-treated or vehicle control rats[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.47mL 0.69mL 0.35mL |
17.34mL 3.47mL 1.73mL |
34.68mL 6.94mL 3.47mL |
| 参考文献 |
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