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CBL0137 HCl

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Chemical Structure| 1197397-89-9 同义名 : CBL-C137 hydrochloride;Curaxin-137 hydrochloride;Curaxin 137;CBLC137;CBL0137 (hydrochloride);Curaxin 137 HCl;CBLC137 HCl;CBL0137 hydrochloride
CAS号 : 1197397-89-9
货号 : A232907
分子式 : C21H25ClN2O2
纯度 : 99%+
分子量 : 372.888
MDL号 : MFCD28160457
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(93.86 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 10 mg/mL(26.82 mM)，配合低频超声助溶
动物实验配方：
生物活性
靶点

  • NF-κB

    NF-κB, EC50:0.47 μM
描述 Administering CBL0137 hydrochloride eliminates viable cells at dosages surpassing 2.5 μM. This compound notably diminishes the number of colonies formed, impacting not just MiaPaCa-2 cells but also those resistant to gemcitabine, such as PANC-1 cells. In human pancreatic cancer cell treatments, CBL0137 hydrochloride leads to a concentration-dependent decrease in the protein and mRNA levels of RRM1 and RRM2[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.68mL

0.54mL

0.27mL

13.41mL

2.68mL

1.34mL

26.82mL

5.36mL

2.68mL
参考文献

[1]Burkhart C, et al. Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer. Oncotarget. 2014 Nov 30;5(22):11038-53.

[2]Gasparian AV, et al. Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT. Sci Transl Med. 2011 Aug 10;3(95):95ra74.