Itacitinib

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Chemical Structure| 1334298-90-6 同义名 : INCB039110; INCB39110; 1334298-96-2
CAS号 : 1334298-90-6
货号 : A231782
分子式 : C26H23F4N9O
纯度 : 99%+
分子量 : 553.514
MDL号 : MFCD28579595
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(54.2 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Itacitinib (INCB039110), an oral, selective JAK1 inhibitor, showcases an IC50 of 2 nM for JAK1, demonstrating over 20-fold selectivity against JAK2 and over 100-fold against JAK3 and TYK21].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.81mL

0.36mL

0.18mL

9.03mL

1.81mL

0.90mL

18.07mL

3.61mL

1.81mL
参考文献

[1]Mascarenhas JO, et al. Primary analysis of a phase II open-label trial of INCB039110, a selective JAK1 inhibitor, in patients with myelofibrosis. Haematologica. 2017 Feb;102(2):327-335.

[2]Alain Lescoat, et al. Combined Anti-Fibrotic and Anti-Inflammatory Properties of JAK-inhibitors on Macrophages in Vitro and in Vivo: Perspectives for Scleroderma-Associated Interstitial Lung Disease. Biochem Pharmacol. 2020 Jun 17;114103.