AMG-47a

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Chemical Structure| 882663-88-9 同义名 : -
CAS号 : 882663-88-9
货号 : A230809
分子式 : C29H28F3N5O2
纯度 : 99%+
分子量 : 535.56
MDL号 : MFCD09970318
存储条件：

Pure form Keep in dark place,Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(65.35 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 AMG-47a is a highly potent and orally bioavailable inhibitor of lymphocyte-specific protein tyrosine kinase (Lck), with an exceptionally low IC50 of 0.2 nM. Beyond its primary target, AMG-47a also effectively inhibits several other kinases, including VEGF2, p38α, Jak3, alongside mixed lymphocyte reaction (MLR) and interleukin-2 (IL-2) production, with IC50 values ranging from 1 nM to 72 nM. These properties equip AMG-47a with significant anti-inflammatory capabilities, marking it as a compound of interest for inflammatory disease research and potential therapeutic development[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.87mL

0.37mL

0.19mL

9.34mL

1.87mL

0.93mL

18.67mL

3.73mL

1.87mL
参考文献

[1]Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity. J Med Chem. 2006 Sep 21;49(19):5671-86.