Crebanine

产品说明书

Print
Chemical Structure| 25127-29-1 同义名 : -
CAS号 : 25127-29-1
货号 : A229845
分子式 : C20H21NO4
纯度 : 97+%
分子量 : 339.39
MDL号 : MFCD01658977
存储条件：

Pure form Keep in dark place,Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(309.38 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Crebanine, a natural product isolated and purified from the herbs of Stephania yunnanensis, can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, decrease the incidence of VF and CA by CaCl_2 in rats and by chloroform in mice, but has no proteetive effects on ouahain-indueed arrhythmias in guinea pigs. Crebanine also has potential utility of crebanine in the development of neurodegenerative therapy, might be used as the starting point to develop a drug for Alzheimer's disease, can inhibit the proliferation of human leukemic cells (HL-60, U937 and K562), human fibrosarcoma cells (HT1080) and cervix cancer cell lines (KB-3-1 and KB-V1 and it mediates cell cycle arrest at G0/G1 phase and this was associated with down-regulation of cyclins A and D.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.95mL

0.59mL

0.29mL

14.73mL

2.95mL

1.47mL

29.46mL

5.89mL

2.95mL
参考文献

[1]Yodkeeree S, Pompimon W, Limtrakul P. Crebanine, an aporphine alkaloid, sensitizes TNF-α-induced apoptosis and suppressed invasion of human lung adenocarcinoma cells A549 by blocking NF-κB-regulated gene products. Tumour Biol. 2014 Sep;35(9):8615-24.

[2]Xiao-Shan H, Qing L, et al. Crebanine inhibits voltage-dependent Na+ current in guinea-pig ventricular myocytes. Chin J Nat Med. 2014 Jan;12(1):20-3.