产品说明书
FDI-6
 |
同义名 : | NCGC00099374 |
| CAS号 : | 313380-27-7 | |
| 货号 : | A229685 | |
| 分子式 : | C19H11F4N3OS2 | |
| 纯度 : | 97% | |
| 分子量 : | 437.434 | |
| MDL号 : | MFCD01416826 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 40 mg/mL(91.44 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | FOXM1 (forkhead box protein M1) is a critical proliferation-associated transcription factor that is widely spatiotemporally expressed during the cell cycle. It is closely involved with the processes of cell proliferation, self-renewal, and tumorigenesis. In most human cancers, FOXM1 is overexpressed, and this indicates a poor prognosis for cancer patients[1]. FDI-6 (forkhead domain inhibitor-6) is an inhibitor of FOXM1. FDI-6 binds directly to FOXM1 protein, to displace FOXM1 from genomic targets in MCF-7 breast cancer cells, and induce concomitant transcriptional down-regulation[2]. MDA-MB-231 ER-negative breast and PEO-1 ovarian cancer cells are sensitive to FDI-6 in cell viability assays (GI50=21.8 μM and 18.1 μM, respectively) and exhibit comparable down-regulation of CDC25B after a 3h treatment with FDI-6[2]. 24h after 10, 20 μM FDI-6 treatment, the apoptosis rate in Hep-2 cells was elevated and the ability of cell invasion and migration was inhibited in a dose-dependent manner. In the nuclear, FoxM1 protein level decreased along with the ascent of FDI-6 concentration[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.29mL 0.46mL 0.23mL |
11.43mL 2.29mL 1.14mL |
22.86mL 4.57mL 2.29mL |
| 参考文献 |
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