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ROS-generating agent 1

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Chemical Structure| 2369030-41-9 同义名 : -
CAS号 : 2369030-41-9
货号 : A2273170
分子式 : C21H15F6NO
纯度 : 98%
分子量 : 411.34
MDL号 : N/A
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(85.09 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 ROS-generating agent 1 covalently modifies the Sec-498 residue of TrxR to generate ROS, resulting in reduced intracellular TrxR protein levels and leading to ROS-dependent apoptosis and ferroptosis of NCI-H460 cells. This agent exhibits anti-cancer activities[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.43mL

0.49mL

0.24mL

12.16mL

2.43mL

1.22mL

24.31mL

4.86mL

2.43mL
参考文献

[1]Songtao Xue, et al. Design, Synthesis, and Biological Evaluation of Novel Hybrids Containing Dihydrochalcone as Tyrosinase Inhibitors to Treat Skin Hyperpigmentation. J Med Chem. 2023 Apr 13;66(7):5099-5117.