Dacinostat

产品说明书

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Chemical Structure| 404951-53-7 同义名 : 达西司特 ;LAQ824;NVP-LAQ824
CAS号 : 404951-53-7
货号 : A226377
分子式 : C22H25N3O3
纯度 : 98+%
分子量 : 379.452
MDL号 : MFCD09970778
存储条件：

Pure form Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 45 mg/mL(118.59 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

5%DMSO+40%PEG300+5%Tween80+50%water 15 mg/mL

生物活性
靶点

  • HDAC

    HDAC, IC50:32 nM
描述 Dacinostat is a highly potent HDAC inhibitor with IC50 of 32 nM and is known to activate the p21 promoter.
细胞研究
细胞系 浓度 检测类型 检测时间 活动说明 数据源
786-0 cells Proliferation assay Antiproliferative activity against human 786-0 cells by SRB assay, GI50=2.38 μM 21621883
A498 cells Proliferation assay Antiproliferative activity against human A498 cells by SRB assay, GI50=1.11 μM 21621883
A498 cells Cytotoxicity assay Cytotoxicity against human A498 cells, LC50=5.88 μM 21621883
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.64mL

0.53mL

0.26mL

13.18mL

2.64mL

1.32mL

26.35mL

5.27mL

2.64mL
参考文献

[1]Wang H, Cheng F, et al. Histone deacetylase inhibitor LAQ824 augments inflammatory responses in macrophages through transcriptional regulation of IL-10. J Immunol. 2011 Apr 1;186(7):3986-96.

[2]Atadja P, Gao L, et al. Selective growth inhibition of tumor cells by a novel histone deacetylase inhibitor, NVP-LAQ824. Cancer Res. 2004 Jan 15;64(2):689-95.