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Toosendanin

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Chemical Structure| 58812-37-6 同义名 : Chuanliansu;28-Deacetylsendanin;BRN-1674886 BRN 1674886;BRN1674886
CAS号 : 58812-37-6
货号 : A225993
分子式 : C30H38O11
纯度 : 98%
分子量 : 574.616
MDL号 : MFCD00210564
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(182.73 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Toosendanin, a natural product isolated and purified from the barks of Melia toosendan Sieb. et Zucc., has effects on the growth, cell cycle arrest, induction of apoptosis and the involved signaling pathway in human promyelocytic leukemia HL-60 cells.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.74mL

0.35mL

0.17mL

8.70mL

1.74mL

0.87mL

17.40mL

3.48mL

1.74mL
参考文献

[1]Yu J, Deng P, et al. Identification of amino acid and glutathione N-conjugates of toosendanin: bioactivation of the furan ring mediated by CYP3A4. Chem Res Toxicol. 2014 Sep 15;27(9):1598-609.

[2]Wu JL, Leung EL, et al. Metabolite analysis of toosendanin by an ultra-high performance liquid chromatography-quadrupole-time of flight mass spectrometry technique. Molecules. 2013 Sep 30;18(10):12144-53.