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Tafamidis

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Chemical Structure| 594839-88-0 同义名 : 他发米帝司甲葡胺 ;PF-06291826
CAS号 : 594839-88-0
货号 : A225692
分子式 : C14H7Cl2NO3
纯度 : 99%+
分子量 : 308.116
MDL号 : MFCD16621109
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(113.59 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Tafamidis functions as a potent and selective stabilizer of transthyretin (TTR), demonstrating similar potency and efficacy to the mutant homotetramers V30M-TTR, V122I-TTR, and wild type WT-TTR, with EC50 values ranging from 2.7 to 3.2 μM. Tafamidis also inhibits amyloidogenesis[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.25mL

0.65mL

0.32mL

16.23mL

3.25mL

1.62mL

32.46mL

6.49mL

3.25mL
参考文献

[1]Bulawa, C.E., et al., Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. Proc Natl Acad Sci U S A, 2012. 109(24): p. 9629-34.