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Esomeprazole Magnesium

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Chemical Structure| 161973-10-0 同义名 : (S)-Omeprazole magnesium;NEXIUM;(–)-Omeprazole Magnesium;(-)-Omeprazole magnesium
CAS号 : 161973-10-0
货号 : A223103
分子式 : C34H36MgN6O6S2
纯度 : 98%+
分子量 : 713.12
MDL号 : MFCD06798050
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(168.27 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 3 mg/mL(4.21 mM)，配合低频超声助溶
动物实验配方：
生物活性
靶点

  • Proton Pump
描述 Esomeprazole magnesium ((S)-Omeprazole magnesium) is a potent orally active inhibitor of H+, K+-ATPase, offering therapeutic potential for research into upper intestinal disorders and gastroesophageal reflux disease[1].[2]. Additionally, it functions as an exosome inhibitor by blocking the release of exosomes through the inhibition of V-H+-ATPases[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.40mL

0.28mL

0.14mL

7.01mL

1.40mL

0.70mL

14.02mL

2.80mL

1.40mL
参考文献

[1]Timothy R Koch, et al. Effect of the H, K-ATPase inhibitor, esomeprazole magnesium, on gut total antioxidant capacity in mice. J Nutr Biochem. 2004 Sep;15(9):522-6.

[2]Pankaj Kumar, et al. Preparation and characterization of pH-sensitive methyl methacrylate-g-starch/hydroxypropylated starch hydrogels: in vitro and in vivo study on release of esomeprazole magnesium. Drug Deliv Transl Res. 2015 Jun;5(3):243-56.

[3]2013 Annual Meeting. Abstract Supplement

[4]Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330.