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Tabersonine

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Chemical Structure| 4429-63-4 同义名 : 它勃宁 ;(–)-Tabersonine
CAS号 : 4429-63-4
货号 : A220793
分子式 : C21H24N2O2
纯度 : 98%
分子量 : 336.428
MDL号 : MFCD28140545
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(74.31 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Tabersonine, a natural product isolated and purified from the root bark of Voacanga africana Stapf, is a precursor for vincristine used in cancer chemotherapy, the biocompatibility and small size essential for permeating the blood-brain barrier make it a potential therapeutic drug candidate for treating AD.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.97mL

0.59mL

0.30mL

14.86mL

2.97mL

1.49mL

29.72mL

5.94mL

2.97mL
参考文献

[1]Kai T, Zhang L, et al. Tabersonine inhibits amyloid fibril formation and cytotoxicity of Aβ(1-42). ACS Chem Neurosci. 2015 Jun 17;6(6):879-88.

[2]Qu Y, Easson ML, et al. Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast. Proc Natl Acad Sci U S A. 2015 May 12;112(19):6224-9.