Methyl nicotinate

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Chemical Structure| 93-60-7 同义名 : 吡啶-3-羧酸甲酯 ;Nicotinic acid methyl ester
CAS号 : 93-60-7
货号 : A218501
分子式 : C7H7NO2
纯度 : 98%
分子量 : 137.14
MDL号 : MFCD00006388
存储条件:

Pure form Keep in dark place,Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(765.64 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 100 mg/mL(729.18 mM),配合低频超声助溶

动物实验配方:
生物活性
描述 Methyl nicotinate (Nicotinic acid methyl ester) serves as an orally active vasodilator with analgesic properties and is known to cause local skin erythema when applied topically. It is employed as an active ingredient in various over-the-counter topical products for researching muscle and joint pain[1].[2].[3].[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

7.29mL

1.46mL

0.73mL

36.46mL

7.29mL

3.65mL

72.92mL

14.58mL

7.29mL

参考文献

[1]Yarosh DB, rt al. Anti-inflammatory activity in skin by biomimetic of Evodia rutaecarpa extract from traditional Chinese medicine. J Dermatol Sci. 2006 Apr;42(1):13-21.

[2]Stringasci MD, et al. MAL-associated methyl nicotinate for topical PDT improvement. J Photochem Photobiol B. 2020 Dec;213:112071.

[3]Elawa S, et al. The microvascular response in the skin to topical application of methyl nicotinate: Effect of concentration and variation between skin sites. Microvasc Res. 2019 Jul;124:54-60.

[4]L. Johnston, et al. Muscle and joint pain: topical anti-inflammatories and analgesics: therapeutic. Professional Nursing Today, Volume 17, Issue 1, Jan 2013, p. 4-5.