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Diacerein

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Chemical Structure| 13739-02-1 同义名 : Diacerhein;Diacetylrhein;SF 277;4,5-Diacetylrhein;DAR
CAS号 : 13739-02-1
货号 : A216806
分子式 : C19H12O8
纯度 : 98%
分子量 : 368.294
MDL号 : MFCD00468030
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 12 mg/mL(32.58 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Diacerein, an anti-OA agent, can significantly inhibit IL-1β production. Both nitric oxide (NO) release and IL-1βsecretion induced by LPS could be reduced by treatment with 1μM Diacerein in human OA synovial tissue. Similar effect of Diacerein could be observed in LPS stimulated human cartilage in culture[1]. The synthesis of MMP-13 induced by IL-1β could be dose-dependently reduced by Diacerein at concentration of 10 and 20μg/ml in subchondral bone explants. Pre-incubation with diacerein for 2 hours with diacerein at 20 μg/mL led to inhibition of ERK1/2 and p38 pathways activated by IL-1β at concentration of 100 pg/mL for 30 minutes in the OA subchondral bone osteoblasts. Differentiation/proliferation of osteoclasts Raw 264.7 cells under RANKL treatment and IL-1β stimulation could be markedly inhibited by 20 μg/mL Diacerein[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.72mL

0.54mL

0.27mL

13.58mL

2.72mL

1.36mL

27.15mL

5.43mL

2.72mL
参考文献

[1]Yaron M, Shirazi I, et al. Anti-interleukin-1 effects of diacerein and rhein in human osteoarthritic synovial tissue and cartilage cultures. Osteoarthritis Cartilage. 1999 May;7(3):272-80.

[2]Boileau C, Tat SK, et al. Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling. Arthritis Res Ther. 2008;10(3):R71.