产品说明书

Thiamphenicol

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Chemical Structure| 15318-45-3 同义名 : Thiophenicol;Dextrosulphenidol;Urfamycine;Masatirin;Hyrazin;Descocin;WIN 5,603-2;(+)-Thiamphenicol;NSC 522822
CAS号 : 15318-45-3
货号 : A216643
分子式 : C12H15Cl2NO5S
纯度 : 98%
分子量 : 356.222
MDL号 : MFCD00467983
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:1个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(294.76 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 2 mg/mL(5.61 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Thiamphenicol is an antimicrobial antibiotic and a methyl-sulfonyl analogue of chloramphenicol. Thiamphenicol showed a significant PAE (0.33 to 2.9h) on all pathogens studied and a powerful bactericidal effect against beta-lactamase-positive and -negative H. influenzae[2]. Moreover, the significant better curative effect of TAF (Thiamphenicol) on BDD M2 (bovine digital dermatitis) lesions was small, compared with ENG (oxytetracycline)[3]. The activity of thiamphenicol was greater than that of erythromycin against H. influenzae and streptococci and equivalent versus Branhamella catarrhalis. In comparison with amoxicillin, the activity of thiamphenicol was higher against H. influenzae and B. catarrhalis and slightly lower against streptococci[4].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00958503 Healthy Phase 1 Completed - Belgium ... 展开 >> SGS Research Unit - Stuivenberg Antwerpen, Belgium 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.81mL

0.56mL

0.28mL

14.04mL

2.81mL

1.40mL

28.07mL

5.61mL

2.81mL
参考文献

[1]Marchese A, Debbia EA, et al. In vitro activity of thiamphenicol against multiresistant Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in Italy. J Chemother. 2002 Dec;14(6):554-61.

[2]Marchese A, Debbia EA, Tonoli E, Gualco L, Schito AM. In vitro activity of thiamphenicol against multiresistant Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in Italy. J Chemother. 2002 Dec;14(6):554-61. doi: 10.1179/joc.2002.14.6.554. PMID: 12583545.

[3]Holzhauer M, Ploegmakers-van Deventer R, Smits D, Swart W. Comparing the curative efficacy of topical treatment with thiamphenicol and oxytetracycline on digital dermatitis lesions in dairy cattle. Vet Rec. 2017 May 20;180(20):500. doi: 10.1136/vr.103758. Epub 2017 May 2. PMID: 28465327.

[4]Albini E, Belluco G, Berton M, Schioppacassi G, Ungheri D. In vitro antibacterial activity of thiamphenicol glycinate acetylcysteinate against respiratory pathogens. Arzneimittelforschung. 1999 Jun;49(6):533-7. doi: 10.1055/s-0031-1300456. PMID: 10417871.