VTP-27999

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Chemical Structure| 942142-51-0 同义名 : -
CAS号 : 942142-51-0
货号 : A215006
分子式 : C26H41ClN4O5
纯度 : 99+%
分子量 : 525.081
MDL号 : MFCD20278231
存储条件：

Pure form Keep in dark place,Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 VTP-27999 is an alkyl amine Renin inhibitor, and is useful for hypertension and end-organ diseases.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01217736 Renal Function Phase 1 Completed - United States, Massachusetts ... 展开 >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.90mL

0.38mL

0.19mL

9.52mL

1.90mL

0.95mL

19.04mL

3.81mL

1.90mL
参考文献

[1]Krop M, Lu X, et al. New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension. 2013 May;61(5):1075-82.

[2]Lanqi J, Robert D S, et al. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility. ACS Med. Chem. Lett., 2011, 2 (10), pp 747–751