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Quercitrin

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Chemical Structure| 522-12-3 同义名 : Quercetin 3-rhamnoside;C.I. 75720;Thujin;Quercetin 3-L-rhamnoside;NSC 9221;Xanthaurine;Meletin;Sophoretin;3-rhamnosyl quercetin
CAS号 : 522-12-3
货号 : A212853
分子式 : C21H20O11
纯度 : 98%
分子量 : 448.377
MDL号 : MFCD00016932
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(267.63 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Quercitrin, a natural product isolated and purified from the herb of Apocynum venetum L. Quercitrin (50, 100, and 200 mg/kg, p.o.) can maintain the level of mitochondrial complex I in injured cells and restore its activity, which reduces the production of ROS (reactive oxygen species), protects the mitochondria from oxidative stress, and has a protective effect on the liver[3]. Intra-articular injection of quercitrin increased bone volume/tissue volume of tibial subchondral bone and cartilage thickness and reduced the Osteoarthritis Research Society International scores in OA (osteoarthritis) rats. Meanwhile, immunohistochemical results showed that quercitrin exerted anti-OA effect by delaying ECM (extracellular matrix) degradation[4]. Quer improves dysregulated lipid metabolism and reduces hepatic steatosis and inflammation by compensating for estrogen deficiency[5]. In addition, quercitrin exhibited the most antiallergic activity against antigen-induced β-hexosaminidase release and IL-4 mRNA expression, which are markers of degranulation in RBL-2H3 cells. After a 7-sensitizing period, 14 days of DNCB (2,4-dinitrochlorobenzene) treatment with or without topical pimecrolimus (1%) or quercitrin (0.5%) treatment, quercitrin was found to suppress DNCB-induced increases in serum IL-4 and IgE concentrations and transepidermal water loss[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.23mL

0.45mL

0.22mL

11.15mL

2.23mL

1.12mL

22.30mL

4.46mL

2.23mL
参考文献

[1]Cincin ZB, Unlu M, et al. Apoptotic Effects of Quercitrin on DLD-1 Colon Cancer Cell Line. Pathol Oncol Res. 2015 Apr;21(2):333-8.

[2]Cincin ZB, Unlu M, et al. Molecular mechanisms of quercitrin-induced apoptosis in non-small cell lung cancer. Arch Med Res. 2014 Aug;45(6):445-54.

[3]Xiong W, Yuan Z, Wang T, Wu S, Xiong Y, Yao Y, Yang Y, Wu H. Quercitrin Attenuates Acetaminophen-Induced Acute Liver Injury by Maintaining Mitochondrial Complex I Activity. Front Pharmacol. 2021 May 5;12:586010

[4]Guo H, Yin W, Zou Z, Zhang C, Sun M, Min L, Yang L, Kong L. Quercitrin alleviates cartilage extracellular matrix degradation and delays ACLT rat osteoarthritis development: An in vivo and in vitro study. J Adv Res. 2020 Jun 24;28:255-267

[5]Hur HJ, Jeong YH, Lee SH, Sung MJ. Quercitrin Ameliorates Hyperlipidemia and Hepatic Steatosis in Ovariectomized Mice. Life (Basel). 2020 Oct 15;10(10):243

[6]Jegal J, Park NJ, Lee SY, Jo BG, Bong SK, Kim SN, Yang MH. Quercitrin, the Main Compound in Wikstroemia indica, Mitigates Skin Lesions in a Mouse Model of 2,4-Dinitrochlorobenzene-Induced Contact Hypersensitivity. Evid Based Complement Alternat Med. 2020 Jul 9;2020:4307161