Niacin

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Chemical Structure| 59-67-6 同义名 : 吡啶-3-甲酸 ;Nicotinic acid;Vitamin B3;NSC 169454
CAS号 : 59-67-6
货号 : A211899
分子式 : C6H5NO2
纯度 : 98%
分子量 : 123.109
MDL号 : -
存储条件：

Pure form Keep in dark place,Inert atmosphere,Room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(406.14 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 10 mg/mL(81.23 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Nicotinic acid, a broad-spectrum lipid agent, could be used against cardiovascular disease [1] . In vitro studies, it was found that nicotinic acid contributed to the secretion of prostaglandin D2 in human macrophages [1] . Besides this, 10-5 M nicotinic acid could also help the synthesis of nicotinamide adenine dinucleotide in the presence of glutamine in ascites cells [2] . In vivo studies, nicotinic acid could stimulate the myelination and increase the ratio of long chain fatty acid (C20-23/C14-18) in weanling rats [3] .
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

8.12mL

1.62mL

0.81mL

40.61mL

8.12mL

4.06mL

81.23mL

16.25mL

8.12mL
参考文献

[1]Meyers CD, Liu P, et al. Nicotinic acid induces secretion of prostaglandin D2 in human macrophages: an in vitro model of the niacin flush. Atherosclerosis. 2007;192(2):253-8.

[2]FRIEDLAND IM, FULLER L, DIETRICH LS. Nicotinic acid and nicotinamide metabolism in ascites cells in vitro. J Biol Chem. 1962.

[3]Nakashima Y, Suzue R. Effect of nicotinic acid on myelin lipids in brain of developing rat. J Nutr Sci Vitaminol (Tokyo). 1982;28(5):491-500.