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Zoledronic acid monohydrate

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Chemical Structure| 165800-06-6 同义名 : 唑来膦酸一水合物 ;Zoledronate monohydrate;CGP42446A monohydrate;Zoledronic Acid (hydrate);CGP-4244 monohydrate;ZOL 446 monohydrate;CGP 42446 monohydrate
CAS号 : 165800-06-6
货号 : A211103
分子式 : C5H12N2O8P2
纯度 : 98%
分子量 : 290.105
MDL号 : MFCD08448695
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 14 mg/mL(48.26 mM)，配合低频超声，并调节pH至8
动物实验配方：
生物活性
描述 Zoledronic acid monohydrate (Zoledronate monohydrate) is a third-generation bisphosphonate (BP) with potent anti-resorptive activity. It inhibits the differentiation and apoptosis of osteoclasts and also exhibits anti-cancer effects [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.45mL

0.69mL

0.34mL

17.23mL

3.45mL

1.72mL

34.47mL

6.89mL

3.45mL
参考文献

[1]Lianwei Wang, et al. Various pathways of zoledronic acid against osteoclasts and bone cancer metastasis: a brief review. BMC Cancer. 2020; 20: 1059.

[2]Hyung Joon Kim, et al. Zoledronate Enhances Osteocyte-Mediated Osteoclast Differentiation by IL-6/RANKL Axis. Int J Mol Sci. 2019 Mar; 20(6): 1467.

[3]Xiao-Lin Huang, et al. Zoledronic acid inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways. Int J Mol Med. 2019 Aug;44(2):582-592.

[4]XIN HUANG, et al. Dose-dependent inhibitory effects of zoledronic acid on osteoblast viability and function in vitro. Mol Med Rep. 2016 Jan; 13(1): 613-622.

[5]Samantha Pozzi, et al. High-dose zoledronic acid impacts bone remodeling with effects on osteoblastic lineage and bone mechanical properties. Clin Cancer Res. 2009 Sep 15;15(18):5829-39.