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Pemetrexed disodium heptahydrate

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Chemical Structure| 357166-29-1 同义名 : LY231514 disodium heptahydrate;Pemetrexed (sodium salt hydrate)
CAS号 : 357166-29-1
货号 : A209789
分子式 : C20H33N5Na2O13
纯度 : 98%
分子量 : 597.481
MDL号 : MFCD09029394
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 100 mg/mL(167.37 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Pemetrexed disodium is a guanine-derived antineoplastic agent that functions as a nucleic acid synthesis inhibitor through its binding to, and inhibition of, thymidylate synthase.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.67mL

0.33mL

0.17mL

8.37mL

1.67mL

0.84mL

16.74mL

3.35mL

1.67mL
参考文献

[1]Vogelzang NJ, Rusthoven JJ, et al. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol. 2003 Jul 15;21(14):2636-44.

[2]Rollins KD, Lindley C. Pemetrexed: a multitargeted antifolate. Clin Ther. 2005 Sep;27(9):1343-82.