产品说明书

MST-312

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Chemical Structure| 368449-04-1 同义名 : Telomerase Inhibitor IX
CAS号 : 368449-04-1
货号 : A207531
分子式 : C20H16N2O6
纯度 : 98%
分子量 : 380.351
MDL号 : MFCD24368986
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(315.5 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 MST-312, also called Telomerase inhibitor IX, is a synthetic compound that acts as a reversible TERT (telomerase) inhibitor, and is described to be more potent than epigallocatechin gallate.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.63mL

0.53mL

0.26mL

13.15mL

2.63mL

1.31mL

26.29mL

5.26mL

2.63mL
参考文献

[1]Morais KS, Guimaraesb AFR, et al. Long-term exposure to MST-312 leads to telomerase reverse transcriptase overexpression in MCF-7 breast cancer cells. Anticancer Drugs. 2017 May 17.

[2]Chung SS, Oliva B, et al. Combination treatment with flavonoid morin and telomerase inhibitor MST‑312 reduces cancer stem cell traits by targeting STAT3 and telomerase. Int J Oncol. 2016 Aug;49(2):487-98.