Triclabendazole

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Chemical Structure| 68786-66-3 同义名 : 三氯苯达唑 ;CGA89317;TCBZ;Egaten.;NVP-EGA230;Fasinex;EGA230B
CAS号 : 68786-66-3
货号 : A206752
分子式 : C14H9Cl3N2OS
纯度 : 98%
分子量 : 359.658
MDL号 : MFCD03147039
存储条件：

Pure form Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(291.94 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Triclabendazole is a benzimidazole derivative that shows anthelminthic activity against Fasciola and Paragonimus[3]. Triclabendazole at 5μM partially protected yeast cells from sugar-induced cell death as shown by increased mean survival time compared to the control group (0.9±0.3d vs. 0.3±0.1d). It also reversed α-synuclein-induced cell death in yeast cells. Pretreatment with 50μM triclabendazole protected rat PC12 cells from H2O2-induced death[4]. Administration of triclabendazole at a dose of 400 mg/kg resulted in a worm burden reduction of < 10% in mice infected with a Liberian strain of S. mansoni[5].
作用机制 Triclabendazole is an anthelminthic and its mechanism of action may involve tegumental disruption via inhibiting microtubule-based processes or adenylate cyclase activity[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.78mL

0.56mL

0.28mL

13.90mL

2.78mL

1.39mL

27.80mL

5.56mL

2.78mL
参考文献

[1]Robinson MW, Trudgett A, et al. Triclabendazole-resistant Fasciola hepatica: beta-tubulin and response to in vitro treatment with triclabendazole. Parasitology. 2002 Mar;124(Pt 3):325-38.

[2]Moll L, Gaasenbeek CP, et al. Resistance of Fasciola hepatica against triclabendazole in cattle and sheep in The netherlands. Vet Parasitol. 2000 Jul 24;91(1-2):153-8.

[3]Gandhi P, Schmitt EK, Chen CW, Samantray S, Venishetty VK, Hughes D. Triclabendazole in the treatment of human fascioliasis: a review. Trans R Soc Trop Med Hyg. 2019;113(12):797-804.

[4]Lee YJ, Burlet E, Wang S, et al. Triclabendazole protects yeast and mammalian cells from oxidative stress: identification of a potential neuroprotective compound. Biochem Biophys Res Commun. 2011;414(1):205-208.

[5]Keiser J, El Ela NA, El Komy E, et al. Triclabendazole and its two main metabolites lack activity against Schistosoma mansoni in the mouse model. Am J Trop Med Hyg. 2006;75(2):287-291.