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Gelsevirine

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Chemical Structure| 38990-03-3 同义名 : -
CAS号 : 38990-03-3
货号 : A206343
分子式 : C21H24N2O3
纯度 : 99+%
分子量 : 352.427
MDL号 : -
存储条件：

粉末

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Gelsevirine, a natural product isolated and purified from the herbs of Gelsemium elegans with anxiolytic activity, may be via the agonist action of glycine receptor in the brain, and can significantly inhibit the proliferation of human carcinoma cell line SW480 and MGC80-3 in a dose-dependent manner, the 50% inhibiting concentration(IC50)of gelsevirine on SW480 cells and MGC80-3 cells are 1.41±0.06 mM and 1.22±0.11 mM respectively.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.84mL

0.57mL

0.28mL

14.19mL

2.84mL

1.42mL

28.37mL

5.67mL

2.84mL
参考文献

[1]Liu M, Huang HH, et al. The active alkaloids of Gelsemium elegans Benth. are potent anxiolytics. Psychopharmacology (Berl). 2013 Feb;225(4):839-51.