产品说明书
Adenine
 |
同义名 : | 腺嘌呤 ;6-Aminopurine;Vitamin B4;NSC 14666 |
| CAS号 : | 73-24-5 | |
| 货号 : | A205648 | |
| 分子式 : | C5H5N5 | |
| 纯度 : | 98% | |
| 分子量 : | 135.127 | |
| MDL号 : | MFCD00041790 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 9 mg/mL(66.6 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 2 mg/mL(14.8 mM)，配合低频超声，并水浴加热至45℃助溶 1M HCl: 20 mg/mL(148.01 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA, with the other three being cytosine (C), guanine (G), and thymine (T). Plasma urea nitrogen (UN) and creatinine levels increased after the oral administration of adenine to mice. However, plasma UN and creatinine levels decreased inversely with the dose of 4APP when a different dosage of 4APP was administered together with adenine. Moreover, from light microscopic observation by hematoxylin-eosin staining, microvacuolic changes in the proximal tubuli were detected in the mouse kidney in the adenine-administered group, and epithelial cell loss, degeneration and microvacuolic changes in the proximal tubuli were observed in the mouse kidney in the adenine-and-allopurinol-administered group[1]. DNA N6-methyladenine is a non-canonical DNA modification that occurs in different eukaryotes at low levels and it has been identified as an extremely important function of life[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
7.40mL 1.48mL 0.74mL |
37.00mL 7.40mL 3.70mL |
74.00mL 14.80mL 7.40mL |
| 参考文献 |
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