产品说明书
Natamycin
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同义名 : | Pimaricin;Antibiotic A 5283;Delvolan;Tennecetin;Synogil;Myprozine;Mycophyt;E 235;Delvocid;CL 12,625 |
| CAS号 : | 7681-93-8 | |
| 货号 : | A204100 | |
| 分子式 : | C33H47NO13 | |
| 纯度 : | 98% | |
| 分子量 : | 665.725 | |
| MDL号 : | MFCD00135085 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 16 mg/mL(24.03 mM)，配合低频超声，并调节pH至6，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Natamycin is an important polyene macrolide antifungal agent produced by several Streptomyces strains and is widely used as a food preservative and fungicide in food, medicinal and veterinary products[3]. Natamycin treatment was associated with significantly better clinical and microbiological outcomes than voriconazole treatment for smear-positive filamentous fungal keratitis, with much of the difference attributable to improved results in Fusarium cases[4]. The interaction of natamycin-azithromycin combination against 60 ocular fungal isolates was tested in vitro. The combination produced 100% synergistic interactions when natamycin was added to azithromycin 20, 40, and 50 μg/ml against Aspergillus flavus species complex (AFSC) isolates and to azithromycin 50 μg/ml against Fusarium solani species complex isolates. Addition of 50 μg/ml azithromycin enhanced natamycin's effect against AFSC isolates by reducing natamycin MIC90 from 64 to 0.031 μg/ml. No antagonism was observed[5]. NAT-SLNs (Natamycin solid lipid nanoparticles) were found to be non-irritating to corneal tissue. NAT-SLNs had a prolonged drug release rate, that improved corneal penetration, and increased antifungal activity without cytotoxic effects on corneal tissues. NAT-SLNs represent a promising ocular delivery system for treatment of deep corneal keratitis[6]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00997035 | Corneal Ulcer ... 展开 >> Eye Infections, Fungal 收起 << | Phase 3 | Completed | - | United States, California ... 展开 >> Proctor Foundation, UCSF San Francisco, California, United States, 94143 India Aravind Eye Hospital Coimbatore, Tamil Nadu, India Aravind Eye Hospitals Madurai, Tamil Nadu, India Aravind Eye Hospital Pondicherry, Tamil Nadu, India Aravind Eye Hospital Tirunelveli, Tamil Nadu, India Nepal Bharatpur Eye Hospital Bharatpur, Chitwan, Nepal Lumbini Eye Institute Bhairahawa, Lumbini, Nepal 收起 << |
| NCT02865876 | Keratitis | Phase 3 | Unknown | March 2017 | Mexico ... 展开 >> Instituto de Oftalmologia Conde de Valenciana Recruiting Mexico City, Mexico, 06800 Contact: Lucero Pedro-aguilar, MD lu.pedroaguilar@gmail.com Contact: Enrique Graue-Hernandez, MD, MSc egraueh@gmail.com 收起 << |
| NCT00516399 | Fungal Keratitis | Phase 3 | Terminated(The DSMC decided it... 展开 >> appeared futile to attempt to demonstrate non-inferiority of povidone-iodine to Natamycin.) 收起 << | - | - |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.50mL 0.30mL 0.15mL |
7.51mL 1.50mL 0.75mL |
15.02mL 3.00mL 1.50mL |
| 参考文献 |
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