产品说明书

Parecoxib

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Chemical Structure| 198470-84-7 同义名 : Vorth-P;Valus-P;SC 69124
CAS号 : 198470-84-7
货号 : A203658
分子式 : C19H18N2O4S
纯度 : 98%
分子量 : 370.422
MDL号 : MFCD25976408
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(134.98 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • COX-2
描述 Parecoxib is a potent and selective COX-2 inhibitor. Parecoxib ameliorated postischemic mitochondria-mediated neuronal apoptosis induced by focal cerebral ischemia in rats and this neuroprotective potential is involved in phosphorylation of Akt and GSK-3β[3]. The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue. The analgesic effects of par and its metabolite val in Wistar rats may be at least partially mediated by a direct interaction with the CB1 receptors[4]. The COX-2 inhibitor parecoxib exerts its analgesic effect on surgical pain through the inhibition of neuronal ERK activation in the spinal cord. COX-2 inhibitor delivery prior to surgery has more potent analgesic effects[5]. Despite the absence of clinical adverse effects, parecoxib can impair anastomotic and abdominal wound healing on a histopathological level[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.70mL

0.54mL

0.27mL

13.50mL

2.70mL

1.35mL

27.00mL

5.40mL

2.70mL
参考文献

[1]Ye Z, Wang N,et al. Delayed administration of parecoxib, a specific COX-2 inhibitor, attenuated postischemic neuronal apoptosis by phosphorylation Akt and GSK-3β. Neurochem Res. 2012 Feb;37(2):321-9.

[2]Meunier A, Aspenberg P. Parecoxib impairs early metaphyseal bone healing in rats. Arch Orthop Trauma Surg. 2006 Sep;126(7):433-6.

[3]Ye Z, Wang N, Xia P, Wang E, Yuan Y, Guo Q. Delayed administration of parecoxib, a specific COX-2 inhibitor, attenuated postischemic neuronal apoptosis by phosphorylation Akt and GSK-3β. Neurochem Res. 2012;37(2):321-329

[4]Schröder H, Höllt V, Becker A. Parecoxib and its metabolite valdecoxib directly interact with cannabinoid binding sites in CB1-expressing HEK 293 cells and rat brain tissue. Neurochem Int. 2011;58(1):9-13

[5]Guo YJ, Shi XD, Fu D, Yang Y, Wang YP, Dai RP. Analgesic effects of the COX-2 inhibitor parecoxib on surgical pain through suppression of spinal ERK signaling. Exp Ther Med. 2013;6(1):275-279

[6]Martinou E, Drakopoulou S, Aravidou E, et al. Parecoxib's effects on anastomotic and abdominal wound healing: a randomized Controlled trial. J Surg Res. 2018;223:165-173