产品说明书

DHFR-IN-4

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Chemical Structure| 2820126-49-4 同义名 : -
CAS号 : 2820126-49-4
货号 : A2021671
分子式 : C18H21N5O2S
纯度 : 98%
分子量 : 371.457
MDL号 : N/A
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 DHFR-IN-4 is a potent inhibitor of dihydrofolate reductase (DHFR), with an IC50 value of 123 nM. Additionally, DHFR-IN-4 displays inhibitory activity against EGFR and HER2, with IC50s of 246 nM and 357 nM, respectively. Notably, DHFR-IN-4 demonstrates remarkable broad spectrum cytotoxic potency against cancer cells[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.69mL

0.54mL

0.27mL

13.46mL

2.69mL

1.35mL

26.92mL

5.38mL

2.69mL
参考文献

[1]Sabry MA, et al. New thiazole-based derivatives as EGFR/HER2 and DHFR inhibitors: Synthesis, molecular modeling simulations and anticancer activity. Eur J Med Chem. 2022 Aug 10;241:114661.