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LJH685

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Chemical Structure| 1627710-50-2 同义名 : -
CAS号 : 1627710-50-2
货号 : A202142
分子式 : C22H21F2N3O
纯度 : 99%+
分子量 : 381.418
MDL号 : MFCD29924738
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(78.65 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 LJH685 is a strong, ATP-competitive, and selective inhibitor of RSK (ribosomal S6 kinase), effectively inhibiting the biochemical activities of RSK1, RSK2, and RSK3 with IC50 values of 6, 5, and 4 nM, respectively[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.62mL

0.52mL

0.26mL

13.11mL

2.62mL

1.31mL

26.22mL

5.24mL

2.62mL
参考文献

[1]Aronchik I, et al. Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers. Mol Cancer Res. 2014 May;12(5):803-12.