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SW044248

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Chemical Structure| 522650-83-5 同义名 : -
CAS号 : 522650-83-5
货号 : A202124
分子式 : C22H23N5O2S
纯度 : 99%+
分子量 : 421.515
MDL号 : MFCD03487851
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 12 mg/mL(28.47 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 SW044248 distinguishes itself as an unconventional inhibitor of Topoisomerase 1 (Top1), manifesting selective toxicity towards certain non-small cell lung cancer (NSCLC) cell lines without impacting Topoisomerase 2 (Top2). In cell lines sensitive to SW044248, such as HCC4017 and H292, concentrations of 2, 5, and 10 µM swiftly suppress transcription, translation, and DNA synthesis. Conversely, these effects are not observed in cell lines deemed insensitive, namely HBEC30KT and HCC44. At a concentration of 10 µM, SW044248 prompts the activation of the integrated stress response via the GCN2 and PKR kinases. The compound's mechanism of toxicity in HCC4017 cells is attributed to the inhibition of Top1. However, at doses of 5 and 10 µM, SW044248 does not affect the HBEC30KT and HCC44 cell lines, possibly due to the upregulation of p21CDKN1A[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.37mL

0.47mL

0.24mL

11.86mL

2.37mL

1.19mL

23.72mL

4.74mL

2.37mL
参考文献

[1]Zubovych IO, et al. A Novel Inhibitor of Topoisomerase I Is Selectively Toxic for a Subset of Non-Small Cell Lung Cancer Cell Lines. Mol Cancer Ther. 2016 Jan;15(1):23-36.