产品说明书

KM11060

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Chemical Structure| 774549-97-2 同义名 : -
CAS号 : 774549-97-2
货号 : A200589
分子式 : C19H17Cl2N3O2S
纯度 : 98%
分子量 : 422.328
MDL号 : MFCD01524977
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(118.39 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 KM11060 is a corrective agent for the F508 deletion (F508del) in the cystic fibrosis transmembrane conductance regulator (CFTR), aiming to address the trafficking malfunction associated with this mutation. This compound has applications in researching the F508del-CFTR processing anomaly and contributes to the advancement of cystic fibrosis studies[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.37mL

0.47mL

0.24mL

11.84mL

2.37mL

1.18mL

23.68mL

4.74mL

2.37mL
参考文献

[1]Robert R, et al. Structural analog of sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect. Mol Pharmacol. 2008 Feb;73(2):478-89.

[2]Wu H, et al. Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. PLoS One. 2014 Mar 26;9(3):e93003.