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Gambogic Acid

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Chemical Structure| 2752-65-0 同义名 : 藤黄酸 A ;Beta-Guttiferrin;GA;Cambogic acid;Beta-Guttilactone;B-Guttiferrin;β-Guttiferin;Guttic Acid;Guttatic Acid
CAS号 : 2752-65-0
货号 : A200522
分子式 : C38H44O8
纯度 : 99% HPLC
分子量 : 628.751
MDL号 : MFCD16878985
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 80 mg/mL(127.24 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

2% DMSO+40% PEG 300+2% Tween 80+water 4 mg/mL

生物活性
靶点

  • Bcl-xL

    Bcl-xL, IC50:1.47 μM

  • Bcl-B

    Bcl-B, IC50:0.66 μM

  • Bcl-w

    Bcl-w, IC50:0.02 μM

  • Bfl-1

    Bfl-1, IC50:1.06 μM
描述 Gambogic acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.59mL

0.32mL

0.16mL

7.95mL

1.59mL

0.80mL

15.90mL

3.18mL

1.59mL
参考文献

[1]Yi T, Yi Z, et al. Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling. Cancer Res. 2008 Mar 15;68(6):1843-50.

[2]Zhang HZ, Kasibhatla S, et al. Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay. Bioorg Med Chem. 2004 Jan 15;12(2):309-17.