产品说明书
H-HoCys-OH
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同义名 : | (S)-2-氨基-4-巯基丁酸 ;NSC 43117;(S)-Homocysteine |
| CAS号 : | 6027-13-0 | |
| 货号 : | A200253 | |
| 分子式 : | C4H9NO2S | |
| 纯度 : | 95% | |
| 分子量 : | 135.185 | |
| MDL号 : | MFCD00151320 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
H2O: 25 mg/mL(184.93 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | L-Homocysteine, a homocysteine metabolite, is a homocysteine that has L configuration. L-Homocysteine induces upregulation of cathepsin V that mediates vascular endothelial inflammation in hyperhomocysteinaemia[3]. L-homocysteine and/or L-homocystine interact in vivo with albumin and other extracellular proteins by forming mixed-disulfide conjugates. Using zinc-Sepharose chromatography, L-homocysteine was shown to impair the zinc-binding capacity of metallothionein even in the presence of reduced glutathione. L-Homocysteine induced a dose-dependent increase in intracellular free zinc in zinquin-loaded human aortic endothelial cells within 30 minutes, followed by the appearance of early growth response protein-1 within 60 minutes. In addition, intracellular reactive oxygen species dramatically increased 6 hours after L-homocysteine treatment. In vitro studies demonstrated that L-homocysteine is a potent inhibitor of the superoxide anion radical scavenging ability of metallothionein[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
7.40mL 1.48mL 0.74mL |
36.99mL 7.40mL 3.70mL |
73.97mL 14.79mL 7.40mL |
| 参考文献 |
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[1]Finkelstein JD, et al. Homocysteine. Int J Biochem Cell Biol. 2000 Apr;32(4):385-9. |