CK2 inhibitor 2

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Chemical Structure| 2641079-92-5 同义名 : -
CAS号 : 2641079-92-5
货号 : A1996716
分子式 : C21H17ClN4O2
纯度 : 95%
分子量 : 392.838
MDL号 : -
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(127.28 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 CK2 inhibitor 2, with an IC50 of 0.66 nM, is a potent, selective, and orally active inhibitor of CK2. It demonstrates high selectivity for Clk2 (IC50=32.69 nM) over CK2 and exhibits favorable antiproliferative and antitumor activity[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.55mL

0.51mL

0.25mL

12.73mL

2.55mL

1.27mL

25.46mL

5.09mL

2.55mL
参考文献

[1]Wang Y, et, al. Discovery of 5-(3-Chlorophenylamino)benzo[ c][2,6]naphthyridine Derivatives as Highly Selective CK2 Inhibitors with Potent Cancer Cell Stemness Inhibition. J Med Chem. 2021 Apr 22;64(8):5082-5098.