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Sodium Salicylate

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Chemical Structure| 54-21-7 同义名 : 2-羟基苯甲酸钠 ;Salicylic acid sodium salt;2-Hydroxybenzoic acid sodium salt;Magsalyl;Kerosal;Kerasalicyl
CAS号 : 54-21-7
货号 : A198464
分子式 : C7H5NaO3
纯度 : 95%
分子量 : 160.1
MDL号 : MFCD00002440
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(655.84 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(624.61 mM)
动物实验配方：
生物活性
靶点

  • NF-κB
描述 Sodium 2-Hydroxybenzoate (Sodium Salicylate) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation[3]. Sodium salicylate and aspirin also inhibited NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells[4]. Sodium salicylate effectively inhibited TNF-alpha-induced upregulation of NF-kappaB, ICAM-1 expression, in-vitro migration and invasion in human melanoma cells, indicating that non-steroidal anti-inflammatory drugs may be a useful therapeutic approach to oppose inflammation-induced melanoma invasion and metastasis in vivo[5]. PC12 cells were treated with different concentrations of sodium salicylate (1-20 mM). Higher concentrations (10-20 mM) killed PC12 cells in a dose-dependent manner. A decreased NF-kappaB activity after sodium salicylate treatment by electrophoretic mobility shift assay (EMSA)[6]. In the RAW264.7 macrophage cell line, suprapharmacological concentrations of sodium salicylate exert a potent inhibitory effect on LPS-induced cytokine gene induction but appear to accomplish this by interfering with NF-kappaB-independent pathways of activation[7]. Moreover, salicylate significantly improved retinal function, as well as reduced TNFα and SOCS3-induced insulin resistance in all samples[8].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.25mL

1.25mL

0.62mL

31.23mL

6.25mL

3.12mL

62.46mL

12.49mL

6.25mL
参考文献

[1]Klampfer L, Cammenga J, et al. Sodium salicylate activates caspases and induces apoptosis of myeloid leukemia cell lines. Blood. 1999 Apr 1;93(7):2386-94.

[2]Kopp E, Ghosh S. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science. 1994 Aug 12;265(5174):956-9.

[3]Mitchell JA, Saunders M, Barnes PJ, Newton R, Belvisi MG. Sodium salicylate inhibits cyclo-oxygenase-2 activity independently of transcription factor (nuclear factor kappaB) activation: role of arachidonic acid. Mol Pharmacol. 1997 Jun;51(6):907-12

[4]Kopp E, Ghosh S. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science. 1994 Aug 12;265(5174):956-9

[5]Katerinaki E, Haycock JW, Lalla R, Carlson KE, Yang Y, Hill RP, Lorigan PC, MacNeil S. Sodium salicylate inhibits TNF-alpha-induced NF-kappaB activation, cell migration, invasion and ICAM-1 expression in human melanoma cells. Melanoma Res. 2006 Feb;16(1):11-22

[6]Kiss K, Kiss J, Rudolf E, Cervinka M, Szeberényi J. Sodium salicylate inhibits NF-kappaB and induces apoptosis in PC12 cells. J Biochem Biophys Methods. 2004 Oct 29;61(1-2):229-40

[7]Lemay S, Lebedeva TV, Singh AK. Inhibition of cytokine gene expression by sodium salicylate in a macrophage cell line through an NF-kappaB-independent mechanism. Clin Diagn Lab Immunol. 1999 Jul;6(4):567-72

[8]Jiang Y, Thakran S, Bheemreddy R, Coppess W, Walker RJ, Steinle JJ. Sodium salicylate reduced insulin resistance in the retina of a type 2 diabetic rat model. PLoS One. 2015 Apr 14;10(4):e0125505