产品说明书
Tebuconazole
 |
同义名 : | BAY HWG-1608 |
| CAS号 : | 107534-96-3 | |
| 货号 : | A198159 | |
| 分子式 : | C16H22ClN3O | |
| 纯度 : | 97% | |
| 分子量 : | 307.818 | |
| MDL号 : | MFCD02674797 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(162.43 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Tebuconazole is an azole fungicide used primarily in agriculture, and it is orally active. It inhibits the CYP51 enzyme with IC50 values of 0.9 μM for Candida albicans CYP51 (CaCYP51) and 1.3 μM for the truncated version of Homo sapiens CYP51 (Δ60HsCYP51). Additionally, tebuconazole has been shown to induce lipid accumulation and oxidative stress in HepG2 cells. It also adversely affects MAC-T cells by reducing their viability and proliferation, inducing ER-stress-mediated apoptosis, and increasing oxidative stress levels[1].[2].[3].[4].[5].[6]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.25mL 0.65mL 0.32mL |
16.24mL 3.25mL 1.62mL |
32.49mL 6.50mL 3.25mL |
| 参考文献 |
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