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Nampt activator-3

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Chemical Structure| 2790481-63-7 同义名 : -
CAS号 : 2790481-63-7
货号 : A1977890
分子式 : C19H20N2O3
纯度 : 99%+
分子量 : 324.374
MDL号 : N/A
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(323.7 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 NAMPT activator-3, a derivative of NAT, activates NAMPT with an EC50 of 2.6 μM and a KD of 132 nM. It effectively protects cultured cells from FK866-mediated toxicity and exhibits strong neuroprotective efficacy in a chemotherapy-induced peripheral neuropathy (CIPN) mouse model without overt toxicity[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.08mL

0.62mL

0.31mL

15.41mL

3.08mL

1.54mL

30.83mL

6.17mL

3.08mL
参考文献

[1]Leibo Wang, et al. Optimization of NAMPT activators to achieve in vivo neuroprotective efficacy. Eur J Med Chem. 2022 Jun 5;236:114260.