产品说明书

BT44

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Chemical Structure| 924759-42-2 同义名 : -
CAS号 : 924759-42-2
货号 : A1949837
分子式 : C28H27F4N3O4S
纯度 : 99%+
分子量 : 577.59
MDL号 : N/A
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(103.88 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 BT44 is a selective RET activator, and demonstrates the capacity to cross the blood-brain barrier, rendering it a promising candidate for the study of neurodegenerative diseases and diabetes mellitus[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.73mL

0.35mL

0.17mL

8.66mL

1.73mL

0.87mL

17.31mL

3.46mL

1.73mL
参考文献

[1]Viisanen H, et al. Novel RET agonist for the treatment of experimental neuropathies. Mol Pain. 2020 Jan-Dec;16:1744806920950866.

[2]Renko JM, et al. Neuroprotective Potential of a Small Molecule RET Agonist in Cultured Dopamine Neurons and Hemiparkinsonian Rats. J Parkinsons Dis. 2021;11(3):1023-1046.