Suzetrigine

产品说明书

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Chemical Structure| 2649467-58-1 同义名 : VX-548
CAS号 : 2649467-58-1
货号 : A1942314
分子式 : C21H20F5N3O4
纯度 : 99%+
分子量 : 473.393
MDL号 : N/A
存储条件：

Pure form Keep in dark place,Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(253.49 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Suzetrigine (VX-548) is an orally bioavailable and remarkably selective inhibitor of NaV1.8, functioning as an analgesic. Additionally, Suzetrigine serves as an antagonist for sodium channel protein type 10 subunit alpha [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.11mL

0.42mL

0.21mL

10.56mL

2.11mL

1.06mL

21.12mL

4.22mL

2.11mL
参考文献

[1]Patricia Korn, et al. Evaluation of 3- and 4-Phenoxybenzamides as Selective Inhibitors of the Mono-ADP-Ribosyltransferase PARP10. ChemistryOpen. 2021 Oct;10(10):939-948.